Tag: mental health

  • The Reality of Living With Depression

    The Reality of Living With Depression

    What Is Depression?

    Studies show that one in five people will experience depression at some point in their life. So what is the reality of living with depression? It’s not just about feeling ‘sad’ or ‘down’ – everyone gets that at some point. Depression is a lot deeper and more insidious. It disrupts your every day life and you can’t just ‘snap out of it.’ This is your trigger warning, this article will discuss suicide and suicidal ideation. Please take care of your mental health if this topic will be too much for you.

    People living with depression will experience a lot of symptoms and difficulties. They lose interest in things they used to enjoy, have changes in weight, difficulties with sleeping, a lack of energy (fatigue) and negative self beliefs and self talk. I am not a mental health professional, I am a person with experience of living with depression. I cannot diagnose or treat and would recommend seeking professional advice.

    Serotonin

    I discussed the neurotransmitters in a previous post. Serotonin is the one most people focus on when we are talking about depression. Low serotonin is common in depression but is more likely to be a symptom than the cause. That said, serotonin is still the basis of pharmaceutical treatment of depression, for example SSRIs, Selective Serotonin Reuptake Inhibitors. A licensed medical professional can advise on appropriate options for treatment.

    Distorted Thinking In Depression

    One of the hallmarks of depression is distorted thinking. Thoughts and emotions that occur that continue the cycle of negativity and the feelings of worthlessness and hopelessness that depression brings. Things like making predictions about the future that are extremely negative. Assuming what other people think of you, and assuming the worst. Telling yourself that everyone hates you, they find you annoying and they only tolerate you because they have to.

    Catastrophising means treating everything that happens as a huge deal, even minor things that go wrong feel like the end of the world. Blaming yourself for everything that goes wrong and obsessing about what you should have done. Even when it isn’t your fault.

    Ignoring the positives and assuming everything will go wrong. Depressed people will often ignore, or not even notice, when something good happens. They only focus on the negative things. They will often self-label as worthless, a failure, useless, all kinds of things that indicate poor self-worth and self-esteem.

    Please understand that none of these things are true and experiencing depression is not your fault, it’s not because you are weak. It is your brain lying to you, in a way. It’s not easy to live with but you can find help and support.

    The Reality of Living With Depression

    People with depression tend to self-isolate and spend excessive time alone. They avoid social engagements and will often make plans then ‘flake out’ at the last minute. They then feel guilty for letting people down and spend their time thinking the worst of themselves.

    Sleep disturbances are common in depression. Either insomnia develops where the person can’t sleep or can’t stay asleep. This makes it harder to break the negative thought cycles as well as worsening fatigue. Other people will sleep too much, spending excessive amounts of time in bed, perhaps even having an inability to get themselves out of bed.

    Appetite can be affected too, either not eating enough or seeking comfort by excessive eating. This can lead to weight loss or gain, which can factor in to more of the negative thought cycles. Emotional dysregulation is very common. Either they are emotionally detached and numb, or experience negative emotions in a very pronounced way. Not just sadness, some people will experience irritability or anger that may seem irrational.

    People will lose interest in things like their hobbies and interests, work and social life. Poor libido is common too. They will stop doing things they enjoy. They will also stop taking care of themselves and their home including hygiene, cleaning the home, making food and that kind of thing. I’ve experienced this and at my worst last year I was showering twice a week and did not care for myself properly.

    People with depression also don’t believe they are worthy of love, care, friendship, respect or consideration from others. They may reject support and avoid reaching out because they believe they are a burden and don’t want to drag other people down with them.

    Living with depression is hard, you are constantly battling your own mind. A lot of people will start self-medicating with substances like alcohol and illegal drugs. This could also be a factor in self-harm behaviours. It’s a coping mechanism, but not a healthy one and long term it will make the situation worse.

    Suicidal Ideation

    This is the most difficult part of depression, both to experience and to talk about. Depression can lead to thoughts of death, self-harm and suicidal ideation. This stems from the belief that the person is worthless, a burden to their friends and family and a belief that everyone around them will be better off without them.

    They may think about ending their life, imagining how to do it and thinking of plans. They may begin making preparations like giving away possessions and that kind of thing. These thoughts are dark and distressing but with depression it can feel like there’s no other way out of the situation.

    If someone admits to feeling this way, please take them seriously and do not judge them. It’s hard to hear when someone you care about wants to end their life, but it is very important that you do not make it about you. Do not call them selfish or tell them how much it will hurt you or other people. They already feel guilty enough, adding more guilt to that will NOT help the situation. Do not dismiss them as dramatic or stupid. If they are in immediate danger, don’t leave them alone and seek professional help for them.

    I think this point bears repeating. Don’t tell a person who has trusted you enough to admit to these feelings, that they will hurt you by taking their own life. No matter how upsetting it is for you to hear, it is also very difficult for them and if you focus on your own feelings instead, you’re manipulating them into feeling guilty about it. Unintentionally, perhaps, but it does not help the person.

    Beware if someone who has depression suddenly seems happy and content. This might not be a sign of them feeling better, it could be that they have made the decision to end their life and they feel good because they know the end is in sight and it is a relief. Especially if they start giving possessions away. Reach out and make sure they know you care.

    How To Help Someone Living With Depression

    There are a lot of things you can do to help someone you know that is living with depression. A lot of it comes down to simply being there for them, show up and support them. Listen to them and don’t dismiss their feelings. Try to avoid offering solutions unless they ask, don’t tell them they’re wrong or that they need to ‘snap out of it.’ Encourage them to seek professional support, help them do this if you can. Remind them that you care and they deserve to be cared about. Gentle encouragement with self-care like nutrition and exercise.

    How To Help Yourself

    Remember that it is not ‘all in your head’, you have an illness, a real illness and it is not your fault. You did nothing to deserve this, you are not lazy and you are not weak. Reach out for help, there are people who want to help you, I promise. Seeing your doctor is an important step to get the help you need.

    Medication can help and it is worth considering, your doctor can help you decide what to try. Talking therapies, counselling and CBT are all options that can help as well. If one thing doesn’t work, that’s okay, you can try something else. Different treatments work better for different people.

    Try not to isolate yourself, you have people around you that care and want to help you. It’s hard to admit when you need help, I know that. But those of us with mental health issues are good at masking, so people might not know what’s going on. It’s okay to not be okay, but it’s okay to put yourself first as well.

    If you need help, Mind has a list of useful contacts. They are there to help. You can find the list here. For those outside the UK, you can easily find helplines via Google that cover where you live. You deserve hope, you deserve help and things can get better. It’s hard to see when you’re in the dark place, but I promise there’s space for you and you are worth helping.

  • Physical Effects of Mental Health: Neurotransmitters

    Physical Effects of Mental Health: Neurotransmitters

    There are many physical effects of our mental health. Neurotransmitters play a huge role in mental and cognitive functions. A lot of people separate mental and physical health issues, and mental health still carries a lot of stigma.

    Scientific background: image of a brain with text 'Mental health matters' then more text 'physical effects of mental health.'

    “It’s all in your head!”

    Except, that doesn’t make it any less real. Mental health problems are real, important and worthy of the same consideration. Neurotransmitters affect nearly all parts of the body in some fashion, which means that mental health issues do have physical effects.

    The full relationship is unclear, whether changes in brain chemistry cause the symptoms and behavioural changes. Or the symptoms and behavioural changes cause the changes in brain chemistry.

    Neurotransmitters are chemical messengers that cross the synapses and bind to receptors to send messages between the neurons and end organs. They either stimulate or inhibit depending on the receptor type. This subject is complex, so we’re going to fous on the important neurotransmitters that matter the most in mental health disorders.

    Serotonin

    A very important neurotransmitter, serotonin is known as 5-hydroxytryptamine or 5-HT. It is a monoamine neurotransmitter produced by the gastrointestinal tract. Enterochromaffin cells release serotonin, which is synthesised from tryptophan in dietary proteins.

    Serotonin regulates mood, cognition, reward, learning, memory and sleep. It also regulates the digestive system, including appetite, vomiting and other digestive processes. It also acts on the blood vessels to manage blood pressure.

    Excessive levels of serotonin result in serotonin syndrome, a serious and potentially life-threatening condition. Overdose or certain combinations of drugs put a patient at risk of serotonin syndrome. For example, combining an SSRI (Selective serotonin reuptake inhibitor) and an MAOI (Monoamine oxidase inhibitor) together. However, serotonin receptors make up important targets for all kinds of pharmaceuticals, including but not limited to mood disorders, anti-emetics (stop vomiting/nausea) and migraine treatments.

    Dopamine

    Known as the ‘pleasure chemical’, dopamine plays many roles in the body. It is a catecholamine neurotransmitter produced in the brain. There are many dopamine pathways, the most important and well known being the ‘reward-motivated behaviour’.

    Anticipation of a reward increases dopamine levels, as do pleasurable experiences. Dopamine plays a role in motor control and managing the release of a number of hormones. Addictive drugs affect dopamine levels and reinforce the cravings and addiction.

    Parkinson’s disease involves the loss of dopamine producing cells in the brain, causing the symptoms of the disease. Dopamine plays important roles in schizophrenia and ADHD as well.

    Dopamine acts as a stimulant to treat low blood pressure, slow heart rates and cardiac arrest, especially useful in newborns. Amphetamines increase dopamine levels in the brain, hence their use in treatment of ADHD, which improves quality of life for lots of people.

    Norepinephrine

    You may know this one as ‘noradrenaline’, both terms are correct but norepinephrine is the general international standard. It is a catecholamine with endocrine (hormone) functions as well. It plays a role in the ‘fight or flight’ response by increasing alertness, vigilance, enchancing memory functions and focusing attention.

    Adrenergic receptors respond to norepinephrine and are a common target for medications. Stimulants increase the amount of norepinephrine. Serotonin-norepinephrine reuptake inhibitors (SNRIs) and amphetamines fit into this category. Antagonistic drugs include beta-blockers which are prescribed to manage anxiety by reducing the heart-rate.

    Stress and anxiety, both acute and chronic, increase the levels of norepinephrine alongside other signalling molecules like epinephrine (adrenaline) and cortisol. Norepinephrine function may also play a role in ADHD. Lack of REM sleep increases norepinephrine secretion and leads to degeneration of the nervous system.

    GABA

    Gamma-aminobutyric acid, the chief inhibitory neurotransmitter in adult mammalian central nervous systems. Growing animals require it for brain development. The pancreatic beta-islet cells produce GABA to inhibit glucagon secretion.

    Many drugs target GABA receptors, including most commonly used anaesthetic drugs like propofol and barbiturates. GABA analogues like pregabalin and gabapentin have anti-convulsant effects and pain management functions.

    Glutamate

    Glutamic acid, an amino acid that humans can produce in the body. This means it’s not an essential amino acid. GABA synthesis uses glutamate as a precursor. It plays a role in learning and memory functions.

    Ketamine modulates glutamate and has proven beneficial in treating depression, especially treatment-resistant depression.

    Glutamate and its salts are a flavour enhancing compound, found in many foods. It gives an umami, or savoury, flavour in foods. A well-known example, monosodium glutamate (MSG) was unfairly maligned in the past.

    MSG naturally occurs in fermented or aged foods like soy sauce, fermented bean paste such as miso, and cheese. MSG is also an additive used in food production. The controversy around it is based in racism against East Asian people. You can eat it, it’s safe.

    Acetylcholine

    An important neurotransmitter, acetylcholine is an ester of acetic acid and choline, the body parts that it affects are called cholinergic. Acetylcholine activates the muscles via the motor neurons, as well as a vital role in the autonomic nervous system. Especially the parasympathetic nervous system.

    In the brain, it is involved in arousal, attention, memory and motivation. Toxins from plants, animals and bacteria act on cholinergic receptors to deactivate or hyperactivate them, causing paralysis.

    Atropine acts on muscarinic cholinergic receptors to treat heart and eye conditions, but excessive doses are toxic. Nicotine acts on nicotinic cholinergic receptors in the brain, which is why nicotine is so powerfully addictive.

    Myasthenia gravis is an autoimmune disorder where antibodies against the acetylcholine receptors cause muscle weakness and fatigue, which is often progressive. In addition, acetylcholine is involved in cognitive decline, Alzheimer’s disease and may also play a role in mood disorders, schizophrenia and ADHD.

    Conclusion

    This summary of neurotransmitters will help as we discuss common mental health disorders and the impact they have on the body. All of these chemical messengers facilitate physical and physiological effects on us.

    We need to discuss mental health more often, reduce the stigma around it and educate people. It’s important, yet often subject to misunderstanding and willful ignorance. Come back next week when we will discuss depression. Thanks for reading! Here’s a short summary of these neurotransmitters and their effects.